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In the field of assisted reproduction<\/strong>, technological and clinical advances have transformed the chances of success in complex cases. One of the most significant approaches of the last decade is the Shanghai Protocol<\/strong>, also known as DuoStim<\/strong>, which has marked a turning point in ovarian stimulation<\/strong>. In this article, we explore what makes it so effective, what the evidence says after 10 years of application, and how we successfully implement it at Cl\u00ednica Fertia<\/strong>.<\/p>\n <\/p>\n The DuoStim Protocol, also known as the Shanghai Protocol, represents an innovation in ovarian stimulation for in vitro fertilisation (IVF) treatments. Unlike traditional methods, this technique performs double ovarian stimulation in the same menstrual cycle \u2014 one in the follicular phase and one in the luteal phase \u2014 which increases the number of mature oocytes available. At Cl\u00ednica Fertia, we have been successfully applying this strategy for more than 8 years in patients with low ovarian reserve, advanced maternal age and women who require urgent fertility preservation due to a cancer diagnosis.<\/p>\n A scientific review published in 2025 has summarised the findings of all studies conducted to date. These are the main points that have been confirmed:<\/p>\n However, there are still some unanswered questions:<\/p>\n The Shanghai Protocol is based on the theory of multiple follicular waves, which demonstrated that the ovaries generate several waves of follicles in each cycle. Taking advantage of both the follicular and luteal phases allows more oocytes to be recruited without compromising their quality. In addition, the high concentration of progesterone in the luteal phase prevents spontaneous ovulation, allowing for more controlled and effective stimulation.<\/p>\n Rather than presenting a new approach, the review article published in 2025 contributes:<\/p>\n This approach has proven to be particularly effective in:<\/p>\nWhat is the DuoStim Protocol and why has it revolutionised fertility?<\/h2>\n
What have we learned 10 years after its implementation?<\/h2>\n
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Physiological basis: why does it work?<\/h2>\n
What does the 2025 scientific review contribute?<\/h2>\n
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Who benefits from the DuoStim Protocol (double ovarian stimulation)?<\/h2>\n