Dual ovarian stimulation (DuoStim): maximise your options in a single cycle
What is dual ovarian stimulation (DuoStim)?
Dual ovarian stimulation, also known as the DuoStim protocol, is an advanced assisted reproduction technique that makes it possible to carry out two ovarian stimulations within the same menstrual cycle.
Unlike conventional IVF, in which a single stimulation is carried out, DuoStim draws on new scientific evidence showing that there are several waves of follicular development throughout the cycle.
This makes it possible to obtain a greater number of oocytes in less time, which is especially important in patients with low ovarian reserve or in situations where time is a key factor.
How it can help you fulfil your dream of becoming a mum
How does the DuoStim protocol work?
The IVF treatment with dual ovarian stimulation is divided into two phases within the same cycle:
First stimulation (follicular phase)
It begins at the start of the menstrual cycle (day 2-3) to stimulate follicular growth and obtain the first oocytes.
Second stimulation
It begins between 3 and 5 days after the first egg retrieval, taking advantage of a second follicular wave.
Both phases are monitored by ultrasound scans and continuous hormonal control by the medical team.
Who is dual ovarian stimulation suitable for?
The DuoStim protocol is particularly recommended for:
Women with low ovarian reserve
Patients of advanced maternal age
Cases where time is limited (such as oncology patients)
Patients who have had a poor response in previous stimulations
At Clínica Fertia we assess each case individually to determine whether this technique is the most appropriate.
Advantages of DuoStim compared with conventional IVF
- Makes it possible to obtain more oocytes in less time
- Reduces the number of cycles required
- Improves the options for patients with a poor response
- Optimises time in fertility treatments
When every cycle counts, making the most of each opportunity makes all the difference.
What is the dual ovarian stimulation process like?
The treatment includes:
Normally, a single egg is produced in each natural cycle. Ovarian stimulation consists of administering hormones by subcutaneous injection in order to obtain more eggs. The whole process is monitored by ultrasound scans, for which we are available seven days a week. Depending on the type of protocol used and how quickly the ovary responds, the process will last between 10 and 12 days.
Once the follicles reach the appropriate number and size, a hormone called HCG is administered to complete the maturation of the eggs. Approximately 36 hours after the HCG is given, the mature eggs can be retrieved from the ovary.
It consists of the aspiration of the mature oocytes under ultrasound guidance and with light sedation, so that the patient does not feel any discomfort. The procedure lasts around 15 minutes.
On that day we recommend not carrying out activities that require your full capacity, such as driving, even if you feel perfectly well.
Once the eggs have been obtained, they are inseminated with the previously processed semen in the laboratory. Sperm selection can be carried out using a technique known as MACS or by conventional capacitation methods such as concentration gradients, Swim Up, etc.
Fertilisation can be carried out by IVF or ICSI. In IVF, the biologist brings each oocyte into contact with the previously selected sperm and lets fertilisation take place on its own. In ICSI, by contrast, a single sperm is introduced into the egg with a very fine needle, around 15 microns in diameter. ICSI is used above all in severe sperm abnormalities, poor oocyte quality, valuable or scarce eggs, advanced maternal age, suspected low fertilisation rate, and cases with previous failure of conventional IVF.
When there is no sperm in the ejaculate (azoospermia) but there is in the testicle, a testicular biopsy (TESE) can be used. In this case the sperm are obtained from testicular tissue and cultured beforehand in the laboratory. The technique used in these cases will always be ICSI.
The embryos are cultured and observed in the laboratory for a few days (2 to 6). For this we have modern incubation techniques to monitor their development in real time (morphokinetics). We have incubators equipped with time-lapse technology, which incorporates an image capture system, allowing us to observe the embryos from fertilisation until the moment of transfer to the uterus, without having to remove them from the incubator. In this way the culture conditions are more stable, which means an improvement in embryo quality. This technology also makes it easier to select the best embryos to transfer and freeze.
The second ovarian stimulation begins five days after the first egg retrieval.
Normally, a single egg is produced in each natural cycle. Ovarian stimulation consists of administering hormones by subcutaneous injection in order to obtain more eggs. The whole process is monitored by ultrasound scans, for which we are available seven days a week. Depending on the type of protocol used and how quickly the ovary responds, the process will last between 10 and 12 days.
Once the follicles reach the appropriate number and size, a hormone called HCG is administered to complete the maturation of the eggs. Approximately 36 hours after the HCG is given, the mature eggs can be retrieved from the ovary.
It consists of the aspiration of the mature oocytes under ultrasound guidance and with light sedation, so that the patient does not feel any discomfort. The procedure lasts around 15 minutes.
On that day we recommend not carrying out activities that require your full capacity, such as driving, even if you feel perfectly well.
Once the eggs have been obtained, they are inseminated with the previously processed semen in the laboratory. Sperm selection can be carried out using a technique known as MACS or by conventional capacitation methods such as concentration gradients, Swim Up, etc.
Fertilisation can be carried out by IVF or ICSI. In IVF, the biologist brings each oocyte into contact with the previously selected sperm and lets fertilisation take place on its own. In ICSI, by contrast, a single sperm is introduced into the egg with a very fine needle, around 15 microns in diameter. ICSI is used above all in severe sperm abnormalities, poor oocyte quality, valuable or scarce eggs, advanced maternal age, suspected low fertilisation rate, and cases with previous failure of conventional IVF.
When there is no sperm in the ejaculate (azoospermia) but there is in the testicle, a testicular biopsy (TESE) can be used. In this case the sperm are obtained from testicular tissue and cultured beforehand in the laboratory. The technique used in these cases will always be ICSI.
The embryos are cultured and observed in the laboratory for a few days (2 to 6). For this we have modern incubation techniques to monitor their development in real time (morphokinetics). We have incubators equipped with time-lapse technology, which incorporates an image capture system, allowing us to observe the embryos from fertilisation until the moment of transfer to the uterus, without having to remove them from the incubator. In this way the culture conditions are more stable, which means an improvement in embryo quality. This technology also makes it easier to select the best embryos to transfer and freeze.
Once the transfer has been carried out, the remaining good-quality embryos are preserved in liquid nitrogen so that they can be used in later cycles. At present, in the Clínica Fertia laboratory we use the technique of Vitrification or ultra-rapid freezing.
It consists of the introduction of the embryos inside the uterine cavity. To do this, a speculum is placed in the vagina and a fine cannula carrying the embryos is introduced; the embryos are deposited in the uterus under ultrasound guidance. This process is quick and painless.
After the transfer we recommend relative rest that day and the following day, and then a return to your usual activity. We only recommend avoiding strenuous effort and sport for the following two weeks. Travelling poses no problem.
Price of dual ovarian stimulation
First stimulation: 3.395€
Second stimulation: 3.000€
First embryo transfer: 1200€
(guided prices)
In addition:
- Free first consultation
- No waiting lists
- Financing available
To receive a personalised quote adapted to your case, we recommend having an initial assessment.
DuoStim at Clínica Fertia: personalised treatment in Málaga
At our fertility clinic we work with a fully personalised approach:
- Individual assessment of each patient
- Team specialising in highly complex cases
- Continuous monitoring
- Laboratory with advanced technology
Our aim is clear: to maximise your chances in the shortest possible time.
Frequently asked questions about dual ovarian stimulation
How many days does a dual ovarian stimulation last?
The full duration of the DuoStim protocol usually spans between 2 and 4 weeks, as it includes two stimulation phases within the same cycle.
How many ovarian stimulations can be carried out?
It depends on each patient, their ovarian reserve and their response to treatment. The specialist will assess how many cycles are advisable in each case.
Does dual ovarian stimulation increase the success rate?
In selected patients, especially those with low ovarian reserve, it can improve the chances by allowing more oocytes to be obtained in less time.
Is DuoStim better than conventional IVF?
Not in every case. DuoStim is indicated for specific profiles, while conventional IVF remains suitable for many patients.
Is it a more aggressive treatment than traditional IVF?
Not necessarily. It is adapted to each patient and carried out under strict medical control to guarantee safety and effectiveness.
Where can I have dual ovarian stimulation in Málaga?
At Clínica Fertia we have specialists in assisted reproduction and experience in advanced treatments such as the DuoStim protocol.
If you have been trying to get pregnant for some time or have been diagnosed with low ovarian reserve, at Clínica Fertia we can help you.
The first fertility appointment is free and includes a personalised assessment to guide you clearly.