What is DNA Fragmentation?
Spermatic DNA fragmentation is one of the causes of male infertility that is also linked to recurrent miscarriages and poor embryo quality.
DNA fragmentation can make pregnancy more difficult even in cases where the semenogram appears normal. In some cases, the oocyte can repair the DNA damage of the sperm that fertilized it, this will depend on the type of DNA lesion, the percentage of sperm DNA affected as well as the quality of the oocyte that is linked to the age of the patient.
Normally, damages to the DNA chain are associated with environmental factors, known as oxidizing agents. In addition, there are other factors that can trigger DNA fragmentation such as having a fever, having a varicocele, smoking or genital tract infections. DNA fragmentation may also increase with age or certain medications and dietary supplements.