Clínica Fertia

High complexity cases

More than 20 years
of experience in
highly complex
fertility cases.

The main pathologies we treat are:

Uterine pathology

The uterus is a key organ in the female reproductive process, it influences implantation failures, repeated miscarriages and obstetric pathologies such as eclampsia, premature birth, premature rupture of membranes or slow development. The presence of uterine fibroids, congenital anomalies, endometrial polyps and uterine synechiae are the main uterine pathologies found in women of a reproductive age, and can be the cause of infertility, repeated miscarriages or premature births.
Here at Clínica Fertia we do a thorough diagnostic study of the uterus to be able to assess the necessary treatment based on the cause. A good medical history is essential, emphasizing the bleeding pattern, regularity of the cycle, presence of dysmenorrhea, pain during sexual intercourse and various other matters of interest. The basic study includes an ultrasound study assessing the presence of pathologies such as fibroids, polyps, etc., and an adequate assessment of the morphology and size of the uterine cavity by means of 2D and 3D scan. Also, in those cases in which it is considered necessary to complete the study a hysteroscopy is done.
It is also very important to assess the receptivity of the endometrium through genetic techniques, in addition to the study of the endometrial microenvironment, presence of an adequate level of saprophytic bacteria (lactobacilli) that favour the implantation of the embryo, as well as ruling out the presence of pathogenic bacteria, which can cause inflammation of the known endometrium such as chronic endometritis that is related to repeated miscarriages and implantation failure. We have genetic and immunohistochemical tests for the study of these specific cases.
In more complex cases, an immunological study is also carried out at the endometrial level., assessing the different populations of immune cells that play a primary role in the phenomenon of implantation and pregnancy development.

In short, we offer a wide range of diagnostic options to then be able to offer the most optimal solutions to the most complex cases in an absolutely personalized way.

Poor response

All women are born with a certain number of oocytes, as they get older their Ovarium Reserve decreases and they have fewer and poorer quality eggs.
The ovarium age does not always correspond to the biological age of a woman, as on occasions, young women can also have a poor ovarium reserve.
Women can have a lower endowment of oocytes than is expected for their age due to being born naturally with a poor ovarium reserve or due to ovarium surgery or pathologies such as endometriosis.

In our fertility clinic we personalize each case by applying stimulation strategies with the aim of obtaining the best quality oocytes with the highest implantation potential that will help us achieve the longed-for pregnancy.

> Double stimulation. A new procedure for Poor Ovarian Reserve.

Implantation failure

The failure of implantation occurs when we have not achieved pregnancy after the transfer of at least two good quality embryos. For a successful embryo implantation to happen, it is necessary to have a suitable embryo, a receptive endometrium and an adequate endometrial microenvironment with an optimal immune response, all these factors work together, favouring not only achieving pregnancy but also its optimal development.

Embryonic, uterine or systemic causes are related to implantation failure.
Here at Clinica Fertia we focus all our efforts on finding out what the cause is by conducting a detailed study that includes tests, imaging techniques, hysteroscopy, immunohistochemical and genetic studies.
We carry out a continuous review of our protocols, updating them based on the latest published research and reports with our goal of always being at the forefront in our field and implementing our results in our clinic.


Endometriosis affects 10% of women and is present in 35% of infertile women. It is the presence of endometrial tissue outside the uterine cavity and it is most frequently located in the ovary, fallopian tubes, ligaments that support the uterus and peritoneum. This ectopic tissue is sensitive to the hormonal changes that occur during the cycle, which is why the most frequent symptom is intense and progressive dysmenorrhea, pelvic pain, although it can sometimes be asymptomatic.
In severe endometriosis, endometriotic implants affecting pelvic structures (intestine, rectum bladder), cause gastrointestinal and urinary symptoms.

It can also be a cause of infertility either because it alters the anatomy of the pelvis and can cause obstruction of the fallopian tubes or it can form endometriotic cysts in the ovary that sometimes requires surgery with the consequent loss of ovarian tissue and follicular reserve.
In our fertility clinic, we have been treating highly complex cases such as severe endometriosis for many years, using antioxidant therapies, as well as various hormonal treatments that help improve the clinical condition of patients and their oocyte quality.

We implement various specific techniques in our reproduction laboratory such as microinjection, prolonged culture and time lapse imaging in order to obtain good quality embryos. As well as tests and specific uterine treatments in order to favour implantation, such as a non-invasive study of receptivity, endometrial microbiome or an immunological study of the endometrium.
Treating the disease with a personalized plan and taking advantage of the different possibilities that reproductive medicine offers us is the key to achieving a successful pregnancy.

Repeated miscarriages

Recurrent miscarriages are defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, although most occur in the first trimester.

50% of the causes are unknown but, in the rest, it is possible to identify the origin. On many occasions, miscarriage occurs because the embryo has a genetic or chromosomal abnormality, there are abnormalities in the number and arrangement of the chromosomes that finally cause it to stop in its development, this being the most frequent cause of miscarriages.

The maternal age is another key factor due to the ovarian reserve of women and the quality of her eggs. Uterine malformations (curettage, polyps, fibroids, or septum uterus) can also be the cause of repeated miscarriages because they prevent the normal growth of the feotus.

Other factors that can also influence repeated miscarriages are endocrine factors (obesity, diabetes mellitus, polycystic ovary syndrome-PCOS- alterations in thyroid hormones), thrombophilias (blood clotting pathologies) or autoimmune diseases (alterations in the maternal immune system). Sometimes the woman can also miscarry because the genetic load provided by the father generates abnormal embryos.

At Clínica Fertia we study the possible causes of each patient, with the aim of significantly reducing the probability of a repeated miscarriage and thus increasing the probability of a successful pregnancy in patients with no other apparent cause of infertility.

Male infertility

Nowadays, 30% of infertility is due to male causes such as testicular and prostatic pathology, duct obstruction, ejaculation or erection disorders and semen disorders.

In our fertility clinic we perform tests such as the basic study of semen analysis. According to the WHO (World Health Organisation), a sample with a sperm concentration of at least 15 million per millilitre is considered normal, with at least 32% of the sperm with progressive motility, and 4% of the sperm with normal morphology.

The findings in the semenogram can determine the presence of different types of abnormalities, in their concentration (oligozoospermia), in their movement (asthenozoospermia), in their shape (teratozoospermia) or in their vitality (necrozoospermia) and in the absence of sperm in the ejaculate (azoospermia). In addition to the basic study of semen, at Clinica Fertia we carry out capacity tests, sperm selection, study of single and double-stranded DNA fragmentation, genetic study of sperm, as well as an exhaustive clinical and endocrinological evaluation of the male.
There are multiple factors that can cause male infertility for example infections, varicocele, ductal obstruction, ejaculatory dysfunction, endocrine disorders, exposure to toxins or genetic alterations of testicular development.
Age and weight are also factors that influence infertility in men, in every case a healthy and balanced lifestyle is always recommended.

At Clínica Fertia we carry out a detailed study to find out what types of anomalies we can be faced with and thus use the appropriate techniques for each case.

Frequently asked questions about reproduction treatments

If you would like more information about our treatments, we are always available to help and answer any of your questions.

How long do I have to wait to start treatment?
If the evaluation is successful, treatment can be started immediately.
Treatment can be scheduled for the month that best suits the couple. In the case of egg recipients, the waiting time is usually one or two months.
How many attempts can I make?

In the case of artificial insemination, here at the clinic we recommend a maximum of four attempts, since 90% of pregnancies occur in the first four cycles.
Regarding In-vitro fertilisation or microinjection, our clinic never makes more than four attempts using these techniques.
In the case of egg donation, it is more difficult to establish a limit, this will normally be determined by psychological and also economic factors.

Can you use these techniques when you have already entered menopause?
Yes. Nowadays, it is possible to become a mother after entering menopause, either physiological due to ovarian failure, or after treatment of neoplastic diseases.
In these cases, the reception of eggs from a donor must be used.
What are the biggest concerns of egg or sperm recipient couples?
Anonymity is what worries most couples and, at Clínica Fertia, this is absolutely always guaranteed. Although a patient accepts to undergo the treatment, they do want the upmost discretion.
Another factor that concerns a couple is the health of the donors and the physical resemblance to them.
In our centre, both in the case of sperm donors and egg donors, our goal is to seek that the physical resemblance is as similar as possible to the parents.
Are these treatments expensive?
For a couple with fertility problems to achieve a pregnancy it can cost between 800 and 6,000 euros, if an assisted reproduction technique is used. Although the price not only depends on the technique used, but also on the frequency of its application.
Clínica Fertia is a pioneer in maintaining an honest and transparent policy. Since 2002 we have published the information of the cost of our treatments on our website.

Check out our prices list